X-Health.show - meet the future of healthcare
The X-Health.show brings to you brilliant minds behind programming living cells, tech that detects pre-term delivery in seconds, brain-computer interface or apps that employ AI to match you, your disease with the best treatment.
For the eXtra Health of the future.
You’ll meet visionaries from Switzerland who push the boundaries of healthcare.
Engineers who teamed up with doctors, scientists turned CEOs, doctors programming AI-powered apps, researchers who abandoned university labs to improve your health.
You’ll hear stories of promising startups founders and successful serial entrepreneurs.
Patients who imagine a better way.
You’ll
learn about new disease treatments
understand how AI-driven health tech can improve your life
grasp the way founders innovate
or even, get inspired to jumpstart innovation at your company.
Luckily, the X-Health.show is based in Switzerland, the most innovative country in the world according to World Intellectual Property Organization. For the 12th consecutive year. No wonder when the abundance of funds for innovation meets the ability to commercialize the discoveries.
With notable research institutions situated nearby top pharmaceutical companies, there’s more to expect. More medical innovations, break-through femtech, life changing biotech, developments in digital health, genetic engineering, and wearables, such as smart ring, blood pressure measurement on your wrist or ECG in your pyjama.
Follow the show to meet these amazing innovators.
X-Health.show - meet the future of healthcare
Off-the-Shelf Scalable Cell Therapies to Cure Cancer, HIV, and More: Dr. Marco Alessandrini, Antion Biosciences
If you heard about miraculous CAR-T cell therapies that cure cancer in one go, my guest today works on something one step further: immunotherapies that are manufactured from healthy donor cells. That means a thousand cancer patients may receive in the future a life-saving shot manufactured ahead and administered when needed.
You may expect
- a fascinating journey into off-the-shelf cell immune therapies of the future
- how the HIV virus works and how understanding this is key to the novel therapy
- the difference between gene editing and gene engineering
- what is gene silencing
- what is microRNA
- and how to administer immune cells from a donor without creating immunowars
Dr. Marco Alessandrini is the CEO of Antion Biosciences. A biochemist and molecular biologist who aims to democratize access to mind-boggling (and very expensive now) cell therapies. A seasoned researcher who beautifully talks about gene and cell engineering.
Antion Biosciences is a Swiss biotech startup developing novel gene and gene-modified therapies thanks to a proprietary multiplex cell engineering platform. Their miCAR T cells are manufactured – hold your breath – from a healthy donor to treat a thousand cancer patients. They are at the beginning of this very promising journey. Follow it on:
https://antionbio.com
Timestamps:
0:00 Dr. Marco Alessandrini and Antion Biosciences
1:24 Donor Cell Therapies for Haematological Cancer Patients: T-Cell Malignancies
3:09 What Are Cell Therapies, Gene-Modified Cell Therapies, Gene Therapies
7:22 The Kiss-And-Kill Effect of T-Cells, CAR-T Cells
13:55 The Limits of Autologous Cell Therapies
16:34 Off-the-Shelf Allogenic Cell Therapies: How to Engineer T-Cells
21:52 How HIV Virus Works
26:25 What is MicroRNA and How to Use It
31:35 Why to Suppress Genes in Cell and Gene Therapies
37:08 The Berlin Patient – the Only Person Cured of HIV, and Gene Suppressing
45:16 Transitioning from Academia to Biotech
49:35 Researching and Improving MicroRNA Technology for Many Other Diseases and Conditions
54:08 Thank You, Follow Antion Biosciences
55:19 Follow X-Health.show, Disclaimer
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The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.
